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Gear We Recommend

Best Aquarium Medications

Quarantine first. These are the treatments keepers reach for when something still goes wrong.

API General Cure 10-Count
Best for: Internal parasites

API General Cure 10-Count

Broad powder treatment used in quarantine protocols.

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API Melafix 16 oz
Best for: Bacterial infections

API Melafix 16 oz

Mild antibacterial for fin and body issues.

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API Pimafix 8 oz
Best for: Fungal issues

API Pimafix 8 oz

Antifungal companion often paired with Melafix.

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Seachem ParaGuard
Best for: External parasites

Seachem ParaGuard

Malachite-free option for ich and flukes in QT.

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API Aquarium Salt 50 lb
Best for: Hospital tanks

API Aquarium Salt 50 lb

Bulk salt for dips and supportive care.

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API Melafix 8 oz
Best for: Bacterial infections

API Melafix 8 oz

Smaller Melafix bottle for QT and mid tanks.

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Seachem ParaGuard 2 L
Best for: Fish rooms

Seachem ParaGuard 2 L

Bulk external parasite treatment.

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Seachem ParaGuard 4 L
Best for: Large systems

Seachem ParaGuard 4 L

Largest ParaGuard for multiple hospital tanks.

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Seachem Focus 5 g
Best for: Medicated food binder

Seachem Focus 5 g

Binds medications to food for internal treatment.

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Seachem MetroPlex 5 g
Best for: Internal parasites

Seachem MetroPlex 5 g

Treats hexamita and similar internal issues.

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API Aquarium Salt 17 oz
Best for: Hospital tanks

API Aquarium Salt 17 oz

Small box of salt for dips and supportive care.

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API MELAFIX Freshwater Fish Bacterial Infection Remedy 4-Ounce Bottle
Best for: Verified Amazon pick

API MELAFIX Freshwater Fish Bacterial Infection Remedy 4-Ounce Bottle

API MELAFIX Freshwater Fish Bacterial Infection Remedy 4-Ounce Bottle

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API AMMO-LOCK Freshwater and Saltwater Aquarium Ammonia Detoxifier 16-Ounce Bottle
Best for: Verified Amazon pick

API AMMO-LOCK Freshwater and Saltwater Aquarium Ammonia Detoxifier 16-Ounce Bottle

API AMMO-LOCK Freshwater and Saltwater Aquarium Ammonia Detoxifier 16-Ounce Bott

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API MELAFIX Freshwater Fish Bacterial Infection Remedy 64-Ounce
Best for: Verified Amazon pick

API MELAFIX Freshwater Fish Bacterial Infection Remedy 64-Ounce

API MELAFIX Freshwater Fish Bacterial Infection Remedy 64-Ounce

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API Melafix for Aquariums, 16oz
Best for: Verified Amazon pick

API Melafix for Aquariums, 16oz

API Melafix for Aquariums, 16oz

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Seachem Cupramine 50 mL / 1.7 fl. oz.
Best for: Verified Amazon pick

Seachem Cupramine 50 mL / 1.7 fl. oz.

Seachem Cupramine 50 mL / 1.7 fl. oz.

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